L’activation de la sirtuin 1 : une nouvelle stratégie neuroprotectrice pour le stress oxydant cérébral in vivo ? Implication dans les effets bénéfiques de l’inhibition de la poly(ADP-ribose)polymérase par le 3-aminobenzamide

L’activation de la sirtuin 1 : une nouvelle stratégie neuroprotectrice pour le stress oxydant cérébral in vivo ? Implication dans les effets bénéfiques de l’inhibition de la poly(ADP-ribose)polymérase par le 3-aminobenzamide

Le stress oxydant (SO) est un mécanisme commun à l’ischémie cérébrale et au traumatisme crânien qui entraîne notamment l’hyperactivation délétère de la poly(ADP-ribose)polymérase (PARP), une enzyme NAD+-dépendante. Cette dernière est impliquée dans le déficit neurologique et la lésion cérébrale cons...

Full description

Bibliographic Details
Main Author:	Gueguen, Cindy
Other Authors:	Paris 5
Language:	fr
Published:	2013
Subjects:	Stress oxydant cérébral Sirtuin 1 (SIRT1) Poly(ADP-ribose)polymérase (PARP) 3-aminobenzamide (3AB) SRT1720 EX527 NAD+ Déficit neurologique Lésion cérébrale Cerebral oxidative stress Poly(ADP-ribose)polymerase (PARP) Neurological deficit Brain lesion 616.81061
Online Access:	http://www.theses.fr/2013PA05P610

Similar Items

3-Aminobenzamide Blocks MAMP-Induced Callose Deposition Independently of Its Poly(ADPribosyl)ation Inhibiting Activity
by: Brian D. Keppler, et al.
Published: (2018-12-01)

The Role of Nicotinamide Adenine Dinucleotide in the Pathogenesis of Rheumatoid Arthritis: Potential Implications for Treatment
by: Weiqian Chen, et al.
Published: (2018-09-01)

Effect of Partial Poly (ADP-ribose) Glycohydrolase Gene Deletion on Cellular Responses to Genotoxic Stress
by: Gao, Hong
Published: (2006)

Changes in NAD/ADP-ribose metabolism in rectal cancer
by: L. Yalcintepe, et al.
Published: (2005-03-01)

Role of SIRT6 in Myofibroblast Cell Death
by: Subramanian, Veena
Published: (2018)

1-Oxo-3,4-dihydroisoquinoline-4-carboxamides as novel druglike inhibitors of poly(ADP-ribose) polymerase (PARP) with favourable ADME characteristics
by: Alexander Safrygin, et al.
Published: (2021-01-01)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
by: Daniel Harrision, et al.
Published: (2020-08-01)

Abstract P-16: Interaction of Poly(ADP-Ribose)Polymerase1 and Poly(ADP-Ribose)Polymerase2 with Nucleosome during Base Excision Repair
by: Mikhail M. Kutuzov, et al.
Published: (2019-06-01)

Editorial: Inhibiting PARP as a Strategic Target in Cancer
by: Kristin eZorn, et al.
Published: (2016-04-01)

PARP Traps Rescue the Pro-Inflammatory Response of Human Macrophages in the In Vitro Model of LPS-Induced Tolerance
by: Julita Pietrzak, et al.
Published: (2021-02-01)

The Role of PARP1 in Monocyte and Macrophage Commitment and Specification: Future Perspectives and Limitations for the Treatment of Monocyte and Macrophage Relevant Diseases with PARP Inhibitors
by: Maciej Sobczak, et al.
Published: (2020-09-01)

Tumor necrosis factor-induced necroptosis is regulated by nicotinamide adenine dinucleotide in a sirtuin-dependent manner
by: Preyat, Nicolas
Published: (2013)

PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting
by: Karolina N. Dziadkowiec, et al.
Published: (2017-02-01)

Nanoparticle Formulations of Poly (ADP-ribose) Polymerase Inhibitors for Cancer Therapy
by: Bijay Singh, et al.
Published: (2020-11-01)

Approches protéomiques appliquées à l'étude de la poly(adp-ribosyl)ation
by: Gagné, Jean-Philippe
Published: (2009)

Three-component Castagnoli-Cushman reaction with ammonium acetate delivers 2-unsubstituted isoquinol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase (PARP)
by: Alexander Safrygin, et al.
Published: (2021-01-01)

Polyclonal BRCA2 mutations following carboplatin treatment confer resistance to the PARP inhibitor rucaparib in a patient with mCRPC: a case report
by: Andrew D. Simmons, et al.
Published: (2020-03-01)

Discovery of 2-(1-(3-(4-Chloroxyphenyl)-3-oxo- propyl)pyrrolidine-3-yl)-1<i>H</i>-benzo[d]imidazole-4-carboxamide: A Potent Poly(ADP-ribose) Polymerase (PARP) Inhibitor for Treatment of Cancer
by: Rui Min, et al.
Published: (2019-05-01)

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol
by: Paul Lesueur, et al.
Published: (2019-03-01)

Structurally unique PARP‐1 inhibitors for the treatment of prostate cancer
by: Ali Divan, et al.
Published: (2020-04-01)

Studies of the metal binding properties and DNA recognition mode of the unusual zinc fingers in poly(ADP-ribose) Polymerase-1 and the investigation of its interaction with apoptosis inducing factor (AIF)
by: Zhou, Ying, 1977-
Published: (2013)

Potentiel des inhibiteurs de poly(ADP-ribose) polymérases seuls ou en combinaison avec la radiothérapie comme nouvelle option thérapeutique pour le carcinome hépatocellulaire
by: Guillot, Clément
Published: (2013)

Poly(ADP-ribose) polymerase-1 : domain C structure, poly(ADP-ribosyl)ation sites and physiological functions
by: Tao, Zhihua, 1977-
Published: (2012)

Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
by: Botta, Davide
Published: (2010)

Resveratrol Activated Sonic Hedgehog Signaling to Enhance Viability of NIH3T3 Cells in Vitro via Regulation of Sirt1
by: Shuang Guo, et al.
Published: (2018-10-01)

Inhibiting poly(ADP-ribosylation) improves axon regeneration
by: Alexandra B Byrne, et al.
Published: (2016-10-01)

Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice
by: Jung-Yeon Kim, et al.
Published: (2019-08-01)

A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy
by: Shah Ashish P., et al.
Published: (2018-03-01)

Structural implications for selective targeting of PARPs
by: Jamin D. Steffen, et al.
Published: (2013-12-01)

The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues
by: Sabira Taipakova, et al.
Published: (2020-11-01)

PARP1 inhibitor (PJ34) improves the function of aging-induced endothelial progenitor cells by preserving intracellular NAD+ levels and increasing SIRT1 activity
by: Siyuan Zha, et al.
Published: (2018-08-01)

Analyses biochimique et protéomique de la poly(ADP-ribosyl)ation
by: Tardif, Maxime
Published: (2011)

Reversing ADP-ribosylation
by: Giuliana Katharina Moeller, et al.
Published: (2017-08-01)

Serine ADP-ribosylation reversal by the hydrolase ARH3
by: Pietro Fontana, et al.
Published: (2017-06-01)

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling
by: Lotte van Beek, et al.
Published: (2021-05-01)

Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo
by: Colin Thomas, et al.
Published: (2016-11-01)

New insights into the mechanism of hepatocyte apoptosis induced by typical organophosphate ester: An integrated in vitro and in silico approach
by: Xiaoqing Wang, et al.
Published: (2021-08-01)

Automodified Poly(ADP-Ribose) Polymerase Analysisto Monitor DNA Damagein Peripheral Lymphocytes of Floriculturists Occupationally Exposed to Pesticides
by: Serena Imperato, et al.
Published: (2019-02-01)

PARP-1 activation regulates the DNA damage response to DNA double-strand breaks
by: Krietsch, Jana
Published: (2014)

SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
by: Jin Young Sung, et al.
Published: (2020-07-01)