La carence en vitamine B12 induit un stress du réticulum endoplasmique dû à une diminution de la déacétylase SIRT1 et une augmentation de l'acétylation de HSF1

La carence en vitamine B12 induit un stress du réticulum endoplasmique dû à une diminution de la déacétylase SIRT1 et une augmentation de l'acétylation de HSF1

La carence en vitamine B12 est fréquente chez les sujets âgés et produit un vieillissement cérébral par des mécanismes malconnus. La vitamine B12 joue un rôle majeur dans les régulations épigénomiques dépendantes de la S-adénosyl méthionine (SAM). Nous avons établi un modèle de cellules neuronales d...

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Bibliographic Details
Main Author:	Ghemrawi, Rose Issam
Other Authors:	Université de Lorraine
Language:	fr
Published:	2013
Subjects:	Vitamine B12 Maladies neurodégénératives Cellules neuronales Stress du RE SIRT1 HSF1 Vitamin B12 Neurodegenerative diseases Neuronal cells ER stress 612.399
Online Access:	http://www.theses.fr/2013LORR0131/document

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