Stratégie du leurre moléculaire en thérapie génique : ciblage de facteurs de transcription par un minicercle d'ADN multisites et étude de l'interaction entre l'ADN platiné et NF-κB

Stratégie du leurre moléculaire en thérapie génique : ciblage de facteurs de transcription par un minicercle d'ADN multisites et étude de l'interaction entre l'ADN platiné et NF-κB

En thérapie génique, la stratégie du leurre moléculaire consiste à utiliser un acide nucléique courtcontenant une séquence spécifiquement reconnue par un facteur de transcription cible, ce qui permetson piégeage intracellulaire et conduit à inhiber l’expression des gènes sous sa dépendance.L’efficac...

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Bibliographic Details
Main Author:	Thibault, Thomas
Other Authors:	Orléans
Language:	fr
Published:	2012
Subjects:	Leurre moléculaire Minicercle d’ADN Thérapie génique Multiciblage Facteur de transcription NF-κB Cisplatine Decoy DNA minicircle Gene therapy Transcription factor NF-κB Cisplatin
Online Access:	http://www.theses.fr/2012ORLE2069/document

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