Fonctionnalité de la signalisation en aval des récepteurs HER : implication dans la réponse cellulaire et tumorale aux thérapies ciblées

Fonctionnalité de la signalisation en aval des récepteurs HER : implication dans la réponse cellulaire et tumorale aux thérapies ciblées

Les thérapies ciblées dirigées contre les récepteurs de la famille des HER représentent un progrès majeur en cancérologie. Leur efficacité repose sur leur capacité à inhiber la signalisation oncogénique notamment recrutant les voies RAS/RAF/MAPK et PI3K/AKT. Indépendamment de l'expression de la...

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Bibliographic Details
Main Author:	Chrétien, Anne-Sophie
Other Authors:	Nancy 1
Language:	fr
Published:	2011
Subjects:	Cancer Cétuximab Panitumumab EGFR Signalisation cellulaire
Online Access:	http://www.theses.fr/2011NAN10050/document

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