Ciblage des lysosomes pour la thérapie enzymatique substitutive ou pour la thérapie photodynamique

Ciblage des lysosomes pour la thérapie enzymatique substitutive ou pour la thérapie photodynamique

Le récepteur du mannose-6-phosphate cation indépendant (RM6P-CI) permet l'endocytose puis le transfert de molécules porteuses du marqueur M6P vers les lysosomes. Pour améliorer à la fois l'affinité pour le RM6P-CI et la stabilité du résidu M6P, nous avons procédé à la synthèse d'analo...

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Bibliographic Details
Main Author:	Salgues, Frédéric
Other Authors:	Montpellier 2
Language:	fr
Published:	2011
Subjects:	Lysosomes Récepteur aux mannose-6-phosphate cation independant Thérapie enzymatique substitutive Maladies lysosomales Thérapie photodynamique Porphyrine Cation-independent mannose 6-phosphate receptor Enzymatic replacement therapy Lysosomal storage disease Photodynamic therapy Porphyrin
Online Access:	http://www.theses.fr/2011MON20148

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