Dérivés de flavonoïdes et de vérapamil comme ligands des transporteurs MRP1 et ABCG2 : de la conception à l'activité anticancéreuse

Dérivés de flavonoïdes et de vérapamil comme ligands des transporteurs MRP1 et ABCG2 : de la conception à l'activité anticancéreuse

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La résistance aux agents chimiothérapeutiques (Multidrug Resistance ou MDR) est caractérisée par la surexpression de différentes protéines membranaires de type ABC, parmi lesquelles, MRP1 et ABCG2 sont largement impliquées. Ces transporteurs diminuent les concentrations intracellulaires des agents c...

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Bibliographic Details
Main Author:	Genoux, Estelle
Other Authors:	Grenoble
Language:	fr
Published:	2011
Subjects:	Flavonoïdes Pharmacomodulation Anticancéreux MRP1 BCRP Flavonoids Anticancer agents Modulators 540 570
Online Access:	http://www.theses.fr/2011GRENV015/document

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