Etude des régions d'insertion membranaire des protéines de la famille Bcl-2 et conception de "poropetides" anticancéreux

Etude des régions d'insertion membranaire des protéines de la famille Bcl-2 et conception de "poropetides" anticancéreux

Les protéines de la famille Bcl-2 sont des régulateurs-clés de l’apoptose (mort cellulaire), qui agissent en contrôlant la perméabilisation de la membrane mitochondriale externe par un processus encore mal connu. La dérégulation des membres de cette famille est souvent associée à la progression tumo...

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Bibliographic Details
Main Author:	Garcia Valero, Juan
Other Authors:	Lyon, École normale supérieure
Language:	fr
Published:	2011
Subjects:	Cytoxicité Famille BCL-2 Anticancer activity Cytotoxicity Pore-forming peptides Proapoptotic bax Antiapoptotic Bfl-1 BCL-2 family
Online Access:	http://www.theses.fr/2011ENSL0618

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