Rôle de la voie IGF-1 dans la sensibilité des plasmocytes tumoraux aux inhibiteurs du protéasome

Rôle de la voie IGF-1 dans la sensibilité des plasmocytes tumoraux aux inhibiteurs du protéasome

Le myélome multiple (MM) est une hémopathie dont la croissance et la prolifération sont liés à une variété de facteurs de croissance, y compris « insulin-like growth factor type 1 » (IGF-1). Bortézomib est le premier inhibiteur protéasome ayant une activité anti-tumorale significative dans le myélom...

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Bibliographic Details
Main Author:	Tagoug, Ines
Other Authors:	Lyon 1
Language:	fr
Published:	2010
Subjects:	Myélome multiple IGF-1 Inhibiteurs de protéasome Bortézomib UPR Stress de réticulum endoplasmique Gadd153 Apoptose Multiple myeloma Proteasome inhibitors Bortezomib Endoplasmic reticulum stress Apoptosis 614.5999
Online Access:	http://www.theses.fr/2010LYO10331

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