Ortho ester-based pH-sensitive cationic lipoplexes for gene delivery
Endosome is a major barrier to efficient gene transfection by synthetic vectors because if the vectors are trapped in the endosome, they will traffic to the lysosome where the DNA is enzymatically degraded. Our hypothesis which serves as the rationale for the design of ortho ester-based lipids and l...
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| Format: | Others |
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Scholarly Commons
2006
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/2629 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=3628&context=uop_etds |