Insulin adsorption to intravenous delivery systems

• Main Author: Zarcone, Michael Joseph
• Format: Others
• Published: Scholarly Commons 1976
• Subjects: Insulin; Drugs Dosage; Parenteral therapy; Medicine and Health Sciences; Pharmacy and Pharmaceutical Sciences
• Online Access: https://scholarlycommons.pacific.edu/uop_etds/1903; https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=2902&context=uop_etds

Lack of quantitative adsorption data makes it difficult for a physician to determine the actual amount of insulin received by a patient against the amount added to the intravenous infusion system. This project was therefore initiated to determine quantitatively the extent of adsorption that would occur in a clinical setting. In order to achieve the above aim, varying amounts of carrier insulin containing I-labeled insulin were added to the intravenous infusion delivery system. Using the most commonly utilized mode of delivery and flow rate the tagged insulin solution was allowed to flow through the intravenous delivery system. Both the amount of activity delivered and the amount of activity remaining in the system were measured.