Study of the aryl hydrocarbon receptor as a target for rational drug design

Study of the aryl hydrocarbon receptor as a target for rational drug design

The aryl hydrocarbon receptor (AhR) heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) for transcriptional regulation. We generated three N-terminal deletion constructs of the human AhR of 12-24 KDa in size—namely D1 (aa 84-295), D2 (aa 84-192) and D3 (aa 191-295)—to supp...

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Bibliographic Details
Main Author: Xie, Jinghang
Format: Others
Published: Scholarly Commons 2014
Subjects:
Pharmacology
Health and environmental sciences
AHR deletion constructs
Aryl hydrocarbon receptor
Aryl hydrocarbon receptor nuclear translocator
CYP1A1
Dioxin response element binding
Hypoxia inducible factor-1
Chemicals and Drugs
Chemistry
Medical Pharmacology
Medicinal-Pharmaceutical Chemistry
Medicine and Health Sciences
Pharmaceutical Preparations
Pharmacy and Pharmaceutical Sciences
Physical Sciences and Mathematics
Online Access:https://scholarlycommons.pacific.edu/uop_etds/140
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1139&context=uop_etds

Internet

https://scholarlycommons.pacific.edu/uop_etds/140
https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1139&context=uop_etds

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