Characterization of AG10, a potent stabilizer of transthyretin, and its application in enhancing in vivo half-life of therapeutic peptides
The misassembly of soluble proteins into toxic aggregates, including amyloid fibrils, underlies a large number of human degenerative diseases. Cardiac amyloidoses, which are most commonly caused by aggregation of Immunoglobulin (Ig) light chains or transthyretin (TTR) in the cardiac interstitium and...
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Scholarly Commons
2016
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| Online Access: | https://scholarlycommons.pacific.edu/uop_etds/130 https://scholarlycommons.pacific.edu/cgi/viewcontent.cgi?article=1129&context=uop_etds |