Molecular and functional characterization of ABRAXAS and PALB2 genes in hereditary breast cancer predisposition

Molecular and functional characterization of ABRAXAS and PALB2 genes in hereditary breast cancer predisposition

Abstract Hereditary mutations in DNA damage response (DDR) genes often lead to genomic instability and ultimately tumor development. However, the molecular mechanism of how these DDR deficiencies promote genomic instability and malignancy is not well understood. Thus, the specific aim of this thesi...

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Bibliographic Details
Main Author: Bose, M. (Muthiah)
Other Authors: Winqvist, R. (Robert)
Format: Doctoral Thesis
Language:English
Published: Oulun yliopisto 2019
Subjects:
DNA damage response
DNA double-strand break repair
G2-M checkpoint
breast cancer
cancer genetics
cancer predisposition
heterozygous germline mutation
replication stress
tumorigenesis
DNA-korjaus
DNA-vauriovaste
G2/M-tarkastuspiste
heterotsygoottinen ituradan mutaatio
replikaatiostressi
rintasyöpä
syöpäalttius
syöpägenetiikka
syövän kehitys
ABRAXAS
BRCA1
CtIP
PALB2
Online Access:http://urn.fi/urn:isbn:9789526218656
http://nbn-resolving.de/urn:isbn:9789526218656

Internet

http://urn.fi/urn:isbn:9789526218656
http://nbn-resolving.de/urn:isbn:9789526218656

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