Regulation of extracellular adenosine level by ADGF-A in \kur{ Drosophila melanogaster}
Regulation of adenosine deaminase-related growth factor A (ADGF-A) expression was studied by preparing a vital GFP reporter system. Ends-in homologous recombination method was adapted to establish a functional reporter system used for localization of ADGF-A protein signal, as well as for clarificati...
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| Format: | Doctoral Thesis |
| Language: | Czech |
| Published: |
2011
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| Online Access: | http://www.nusl.cz/ntk/nusl-54770 |
| Summary: | Regulation of adenosine deaminase-related growth factor A (ADGF-A) expression was studied by preparing a vital GFP reporter system. Ends-in homologous recombination method was adapted to establish a functional reporter system used for localization of ADGF-A protein signal, as well as for clarification a conditions and regulation level of enzyme expression. This thesis uncovers a piece of puzzle on our understanding of adenosine signaling and its regulation during immune response in Drosophila melanogaster. |
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