$Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}$

Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}

The aim of this work was to examine the function of the nuclear effectors of JNK signaling, Jun and Fos, in insect telotrophic ovaries, and compare it to the polytrophic ovary of Drosophila. RNA interference knockdown of Jun and Fos in the beetle Tribolium castaneum blocked oogenesis by causing deat...

Full description

Bibliographic Details
Main Author:	SMÝKAL, Vlastimil
Format:	Dissertation
Language:	Czech
Published:	2008
Online Access:	http://www.nusl.cz/ntk/nusl-49454

id	ndltd-nusl.cz-oai-invenio.nusl.cz-49454
record_format	oai_dc
spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-494542018-10-04T06:51:51Z Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum} Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum} SMÝKAL, Vlastimil The aim of this work was to examine the function of the nuclear effectors of JNK signaling, Jun and Fos, in insect telotrophic ovaries, and compare it to the polytrophic ovary of Drosophila. RNA interference knockdown of Jun and Fos in the beetle Tribolium castaneum blocked oogenesis by causing death of follicle cells during growth of the vitellogenic oocytes through caspase-dependent apoptosis. Jun and Fos are therefore required for follicle cell maintenance, which is not the case in Drosophila. Since knockdown of the Jun N-terminal kinase (JNK) had no such effect, Jun and Fos likely act downstream of another kinase during Tribolium oogenesis. We propose that Jun and Fos ensure follicle cell survival upon physical stretching of the follicle epithelium resulting from the oocyte growth. 2008 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-49454 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	The aim of this work was to examine the function of the nuclear effectors of JNK signaling, Jun and Fos, in insect telotrophic ovaries, and compare it to the polytrophic ovary of Drosophila. RNA interference knockdown of Jun and Fos in the beetle Tribolium castaneum blocked oogenesis by causing death of follicle cells during growth of the vitellogenic oocytes through caspase-dependent apoptosis. Jun and Fos are therefore required for follicle cell maintenance, which is not the case in Drosophila. Since knockdown of the Jun N-terminal kinase (JNK) had no such effect, Jun and Fos likely act downstream of another kinase during Tribolium oogenesis. We propose that Jun and Fos ensure follicle cell survival upon physical stretching of the follicle epithelium resulting from the oocyte growth.
author	SMÝKAL, Vlastimil
spellingShingle	SMÝKAL, Vlastimil Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
author_facet	SMÝKAL, Vlastimil
author_sort	SMÝKAL, Vlastimil
title	Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
title_short	Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
title_full	Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
title_fullStr	Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
title_full_unstemmed	Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}
title_sort	role of jun and fos in oogenesis of the beetle \kur{tribolium castaneum}
publishDate	2008
url	http://www.nusl.cz/ntk/nusl-49454
work_keys_str_mv	AT smykalvlastimil roleofjunandfosinoogenesisofthebeetlekurtriboliumcastaneum
_version_	1718760597587230720

Role of Jun and Fos in oogenesis of the beetle \kur{Tribolium castaneum}

Similar Items