| Summary: | THE ROLE OF INTRACELLULAR IRON IN LYMFO/MONOCYTES IN ATHEROGENETIC PROCESS MUDr. Peter Riško Background: The increased storage iron level is connected to a higher frequency of cardiovascular events (CVE). Aims and hypothesis: The study investigates the relationship between LIP (labile iron pool) in circulating monocytes and markers of iron metabolism and atherosclerosis (inflammation, oxidative stress, endothelial dysfunction and arterial elasticity) in patients with chronic cardiovascular disease and in healthy volunteers and in long-term blood donors and healthy non-donor volunteers. Methods: A detailed medical history was obtained from the probands and anthropometric measurements (body height, weight and waist, calculation of body mass index and waist-hip ratio) were performed. The following parameters were measured / calculated for all respondents: blood pressure (systolic / diastolic), ankle-brachial index (ABI), pulse pressure and mean arterial pressure, cardio-ankle vascular index (CAVI), augmentation index (AI), pre-ejection time (PEP) and ejection time (ET), sonographic examination of abdomen and carotid arteries were performed. Blood samples were collected in the morning after at least 10 hours of fasting. We performed a basic biochemical examination and measured the parameters of inflammation,...
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