Syntéza analog chelátoru SIH se zvýšenou stabilitou vůči hydrolýze

• Main Author: Kruchkou, Pavel
• Other Authors: Karabanovich, Galina
• Format: Dissertation
• Language: Czech
• Published: 2021
• Online Access: http://www.nusl.cz/ntk/nusl-453400

Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Supervisor: Ing. Galina Karabanovich, Ph.D. Student: Pavel Kruchkou Title of Thesis: Synthesis of analogues of chelator SIH with increased stability towards hydrolysis Excessive amounts of free iron ions in the body can catalyze the formation of hydroxyl radicals, which are involved in the development of various diseases. One of the ways how to protect the body is to chelate free iron ions with chelators, in order to prevent the development of iron- catalyzed oxidative stress. Effective chelators are substances from the group of salicylaldehyde analogues of isonicotinoyl hydrazone. Salicylaldehyde isonicotinoyl hydrazone (SIH) is a chelator that forms complexes with Fe 3+ ions. Due to its high lipophilicity can be administered orally. Its main disadvantage is the low stability in the aqueous environment caused by the rapid hydrolysis of the hydrazone bond. The aim of this work was to synthesize a series of new aroylhydrazones derived from the SIH chelator, which supposed to have an improved ability to chelate iron ions and the associated ability to protect cells from oxidative stress and potentially increased stability to hydrolysis. In the first series of SIH analogs - N...