Vliv kouření na farmakodynamiku a farmakokinetiku léčiv II - rešeršní práce

• Main Author: Michalíková, Adéla
• Other Authors: Doseděl, Martin
• Format: Dissertation
• Language: Czech
• Published: 2020
• Online Access: http://www.nusl.cz/ntk/nusl-450630

INFLUENCE OF SMOKING ON DRUG'S PHARMACODYNAMICS AND PHARMACOKINETICS II Author: Mgr. Adéla Michalíková Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Introduction: The interaction between smoking cigarettes and using some types of drugs can significantly affect pharmacotherapy. For example, reducing of therapeutic effect or occurrence of side effects can be caused by smoking cigarettes. Aims: The aim of the study was to describe and summarize information about interaction between smoking and selected drugs. Methods: Sources were searched by bibliographic database such as PubMed and by web-search engine Google Scholar, in this diploma thesis. Examples of searched keywords are "smoking", "drug's interaction", "pharmacokinetics", "pharmacodynamics" etc. Keywords were entered individually or in combination. The most related articles were chosen for this thesis. From book sources, Stockley's drug interaction was used to search about information of drug's interactions with smoking. Results: The available literature indicates that the mechanism of the interaction between smoking and drugs is largely at the pharmacokinetic level, in particular by increasing drug metabolism by induction of...