| Summary: | Enterotoxins produced by Staphylococcus aureus can act as superantigens and thus, regardless of the antigenic specificity, influence the course of chronic rhinosinusitis with nasal polyps (NP). The aim of this study was to determine if antibiotic treatment administered after endoscopic sinus surgery (ESS) for NP can positively influence the course of the disease compared to placebo. After ESS, 23 patients which tested positive, in a perioperative culture, for SA strains producing enterotoxins A - E and TSST-1, were randomized into 2 groups. Group A (13 patients), which in addition to treatment with intranasal steroids and saline douches, received oral anti-staphylococcal antibiotics (according to the minimal inhibitory concentration) for 3 weeks. Group B (10 patients) received a placebo. Both groups were compared preoperatively, then again at 3 and 6 months after surgery using a symptom-specific score, an endoscopic score and the SNOT-22 quality of life questionnaire. Slightly better results were achieved in patients who received antibiotic therapy. However, the differences were not statistically significant. The biggest difference was seen on the endoscopic score 3 months after surgery. This difference clearly favored patients in group A. Regardless of post-operative treatment, approximately 30 % of...
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