Vliv predoperační radiochemoterapie na expresi vaskulárního endoteliálního růstového faktoru a hustoty CD8+ tumor infiltrujících lymfocytů adenokarcinomu rekta

• Main Author: Buka, David
• Other Authors: Petera, Jiří
• Format: Doctoral Thesis
• Language: Czech
• Published: 2021
• Online Access: http://www.nusl.cz/ntk/nusl-448436

Rectum adenocarcinoma is one of the most frequent tumour diseases in the Czech Republic. Therefore any progress in therapy or prevention of this disease can have a significant impact on mortality and morbidity of major amount of oncological patients. Within therapy the neoadjuvant concomitant radiochemotherapy or the sole radiotherapy is used before surgical resection in one third to half of all newly diagnosed cases. The goal is to achieve tumor downstaging and local relaps probability decrease. There is a large amount of processes on molecular and cellular level in organism reaction to neoplasia genesis, whose understanding can have a substantial impact on therapy's success rate or on therapy's efficiency prediction. One of these processes is angiogenesis induced by high production of vascular endothelial growth factor (VEGF). As per immunohistochemical studies VEGF is not expressed in typical colorectum mucous membrane. However it is strongly expressed in case of adenocarcinoma. Another important process of organism's malignancy response is tumour tissue infiltration by CD8+ T lymphocytes (TIL), which are one of the important components of cellular immunity against tumour and which significantly contribute to tumour cells elimination. Potential of CD8+ T lymphocytes is considerable not just in...