Perorální imunologická tolerance - potravinové alergie

• Main Author: Chludová, Helena
• Other Authors: Rathouská, Jana
• Format: Dissertation
• Language: Czech
• Published: 2020
• Online Access: http://www.nusl.cz/ntk/nusl-436848

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medicinal Sciences Consultant: PharmDr. Jana Rathouská, Ph.D. Candidate: Helena Chludová Title of diploma thesis: Oral immunological tolerance - food allergies Food allergy is a pathological immune response caused normally by harmless food antigens. At this time, treatments are based on the management of avoidance of potential allergens and immediate treatment of allergic reactions. The prevalence of the disease is increasing while the level of care remains insufficient. Therefore, accurate diagnosis and appropriate prevention seem to be the key to reduce successfully the prevalence of food allergies. The fact of the matter is that oral tolerance generally occurs on mucosal surfaces. It primarily suppresses specific immune responses to antigens in the gastrointestinal tract. Furthermore, the process protects against an inappropriate immune response to a number of foreign antigens or common commensal organisms in the digestive tract. Indeed, if oral tolerance fails, immune reactivity leads to food allergies. During the last decade, research has considerably focused on the timing of the introduction of solid and potentially allergenic foods in infant nutrition. This early period of life is associated with...