Účinky a metabolismus anthelmintik v pícninách

• Main Author: Nováková, Anežka
• Other Authors: Skálová, Lenka
• Format: Dissertation
• Language: Czech
• Published: 2020
• Online Access: http://www.nusl.cz/ntk/nusl-411821

Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Anežka Nováková Supervisor: prof. RNDr. Lenka Skálová, Ph.D. Consultant: Ing. Lenka Langhansová, Ph.D. Title of diploma thesis: The effects and metabolism of anthelmintics in fodder plants Drugs are potentially dangerous contaminants of the environment. The entry of anthelmintics into the environment is mainly via excrement of treated animals. Anthelmintics can negatively affect the ecosystem by acting on non-target organisms such as plants and soil microorganisms. The accumulation of medicines in plants is also at risk. The consumption of these plants may promote the development of resistance in helminths. This thesis looked at the study of the influence and biotransformation of frequently used anthelmintics of albendazole (ABZ), ivermectin (IVM) and monepantel (MOP) in the forage plants of alfalfa seté (Medicago sativa) and the meadow clover (Trifolium pratense). Plants cultivated in in vitro conditions and plants grown in a greenhouse were used for evaluation. Phytotoxicity was monitored on seeds and whole plants by measuring the length of the roots, by determining the content of proline, light-collecting pigments and the total protein content. Mild phytotoxicity was observed after ivm...