Předoperační diagnostika karcinomu prostaty

• Main Author: Dolejšová, Olga
• Other Authors: Hora, Milan
• Format: Doctoral Thesis
• Language: Czech
• Published: 2018
• Online Access: http://www.nusl.cz/ntk/nusl-389623

Preoperative diagnostic methods in prostate cancer Introduction: At present, the most attention in prostate cancer is focused on tumor markers and imagining methods, especially magnetic resonance and fusion methods in order to accurately identify carcinoma deposits and predict the biological behavior of the tumor. Accurate diagnosis allows choosing optimal therapeutic procedure. Aim: The aim of the study is to evaluate how preoperative diagnostic methods can help in designing an optimal treatment in a patient with prostate cancer. The main objective is to evaluate the use of the Prostate Health Index (PHI) in differentiating low-risk carcinoma from aggressive cancer. Another goal of the thesis is the use of imaging methods. I focused on the 3T magnetic resonance imaging in assessing invasion beyond the prostate and in high risk patiens on a new method of fusion magnetic resonance imaging and positron emission tomography for prediction of nodal involvement. Methodology: A total of 320 patients who underwent preoperative diagnosis using our investigated methods (PHI, MRI, choline PET / MRI) and subsequently radical prostatectomy were enrolled in the study. It allowed us to retrospectively assess these diagnostic tests. The PSA, % fPSA, -2proPSA, and PHI results overall were evaluated by statistical...