Vliv teploty sušení na vlastnosti sprejově sušené laktosy

• Main Author: Slezáčková, Jana
• Other Authors: Svačinová, Petra
• Format: Dissertation
• Language: Czech
• Published: 2017
• Online Access: http://www.nusl.cz/ntk/nusl-356067

Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Jana Slezáčková Title of Thesis: The effect of the drying temperature on the properties of spray-dried lactose The aim of this work was to investigate the effect of inlet temperature on the physicochemical properties of spray dried lactose. 10% lactose solution was prepared by dissolving D-lactose monohydrate in distilled water and subsequently dried in a laboratory-scale spray drier. The inlet temperature of 130 řC - 200 řC was used. The physicochemical properties of lactose particles was investigated by optical microscopy and differential scanning calorimetry. Results indicated the influence of inlet temperature on particle size and shape and thermal properties of dried material. The morphology of spray-dried lactose showed tendency to higher sphericity when higher temperatures in a spray-drying process were used. Most of particles was in range 2,5 - 7,5 μm. The particles larger than 20 μm wasn't observed at the inlet temperature of 150 - 200 řC. At the inlet temperature over 150 řC the glass transition temperature was noticed. The glass transition temperature was observed around 24,8 - 63,5 řC. It was evident that higher drying temperature...