Determinanty mikrovaskulárních a makrovaskulárních komplikací diabetes mellitus

• Main Author: Piťhová, Pavlína
• Other Authors: Kvapil, Milan
• Format: Doctoral Thesis
• Language: Czech
• Published: 2015
• Online Access: http://www.nusl.cz/ntk/nusl-351008

Background: Diabetes mellitus both type 1 and 2 rank among the strongest predictors of cardiovascular diseases (CVD). We studied differences between type 1 and 2 diabetic women regarding association of risk factors and microvascular complications and association of cardiovascular risk factors with preclinical atherosclerosis expressed as intima-media thickness of common carotid and femoral arteries. Patients and methods: Women with type 1 (n=203) and type 2 diabetes (n=123) were examined. Microvascular complications were analyzed as follow: retinopathy, nephropathy, neuropathy and diabetic foot syndrome and their risk factors. Preclinical atherosclerosis markers expressed as ankle- brachial index (ABI) and toe-brachial index (TBI) and intima-media thickness of common carotic (IMT CCA) and femoral (IMT CFA) arteries meassured by high resolution ultrasound were analyzed with regard to the presence of cardiovascular risk factors. Most important results: No serious differences in risk factors for development of microvascular diabetic complications were found. Concerning preclinical atherosclerosis risk factors in type 1 diabetic women strong association between IMT CCA and body mass index, waist circumference, and total body fat was found in contrast to type 2 diabetic women. In type 2 diabetic women...