Léčba závažné tyreoidální orbitopatie hemoreoferézou, význam změn vybraných patogenetických činitelů

• Main Author: Ceeová, Věra
• Other Authors: Čáp, Jan
• Format: Doctoral Thesis
• Language: Czech
• Published: 2015
• Online Access: http://www.nusl.cz/ntk/nusl-350945

Haemorheopheresis in treatment of severe thyroid associated orbitopathy, the role of changes in selected pathogenetic indicators Introduction: Thyroid associated orbitopathy (TAO) is an autoimmune disease characterized by inflammatory swelling and cellular infiltration of orbital tissues. In severe cases causes disablement and disfigurement of patients. The treatment of choice has been for many years corticosteroid treatment. Its benefit was clearly demonstrated in spite of many important adverse events. The effect of other immunosuppressive treatment has not been clearly demonstrated. Objective: The aim of our study was to determine the effect of haemorheopheresis on the course of TAO in patients with very severe form of disease in a randomized study (10 patients treated with high doses of glucocorticosteroids and 10 patients on combination of glucocorticosteroids and haemorheopheresis). Secondary aim is to follow selected pathogenetically important immunological and biochemical parameters during haemorheopheretic treatment and to evaluate safety and tolerability of our method modification. Patients and methods: 20 patients with very severe form of disease, without improvement on standard glucocorticoid treatment were enrolled into the study. They were randomized into two groups. Ten patients were treated...