Chemerin a omentin: vztah k tělesné hmotnosti a kardiometabolickým rizikům u českých adolescentů

• Main Author: Macháčková, Eva
• Other Authors: Zamrazilová, Hana
• Format: Dissertation
• Language: Czech
• Published: 2016
• Online Access: http://www.nusl.cz/ntk/nusl-350772

Epidemic of obesity is dangerous because of cardiometabolic health risks associated with it. The growing worldwide prevalence of obesity, even in pediatric population, goes hand in hand with efforts for finding new ways of treatment. Therapy with hormones of adipose tissue, adipokines, is one of the considered options. Chemerin and omentin are promising candidates for obesity treatment. Not many researches regarding adipokines and obese pediatric patients were published and the data from omentin researches are controversial. The aim of this diploma thesis is investigation of chemerin and omentin level differences between slim and obese Czech adolescents. Additionally, if hormone levels of adipokines correlate with observed anthropometric and biochemical parameters. Next, if chemerin and omentin levels differ with respect to diagnostic methods of metabolic syndrome. In addition, if these hormone levels change depending on weight reduction. Together 122 obese (BMI ≥ 97. percentile) and 162 slim (BMI 25.-75. percentile) girls and boys aged from 13,0 to 17,9 years were studied. Physical examination included basic clinical biochemical and anthropometric measurements. ELISA method for blood plasma examination was used for chemerin and omentin level investigation. Obese individuals underwent examination...