Modulace imunitních reakcí myší vybranými helminty

• Main Author: Pavlíková, Veronika
• Other Authors: Chanová, Marta
• Format: Dissertation
• Language: Czech
• Published: 2016
• Online Access: http://www.nusl.cz/ntk/nusl-348316

Currently, the use of helminths in alternative treatment of immune mediated diseases is an attractive topic. Their therapeutic potential is justified by the ability to modulate the host immune system. To test this potential, we chose the flukes of Schistosoma mansoni, which is known to immunomodulate its hosts significantly, however also act as a strong pathogen. Due to high pathogenicity of classical infections we tried to compare its immunomodulation efficiency with alternative interactions of S. mansoni with the host. We tested a low-dose infection, nonproductive infection, immune stimulation with living or dead eggs (antigens) and restimulation by both, living and dead eggs. Stimulation with eggs was, for the short term, most effective in suppressing inflammatory immune response. From the long term point of view, low-dose infections. were most effective. Use of egg antigens has affected the immune system very poorly and nonproductive infection had no effect at all. Induction of experimental colitis and differences in the subsequent development in various models partially confirm our findings.