Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek

Charles University Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry University of Limoges Faculty of Pharmacy Laboratory of Natural Substances Chemistry Consultants: prof. RNDr. Milan Pour, Ph.D., Dr. Christelle Pouget Student: Lukáš Novotný Title of Thesis: Synthe...

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Main Author: Novotný, Lukáš
Other Authors: Pour, Milan
Format: Dissertation
Language:English
Published: 2016
Online Access:http://www.nusl.cz/ntk/nusl-348068
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spelling ndltd-nusl.cz-oai-invenio.nusl.cz-3480682017-06-29T04:17:22Z Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek Synthesis and characterisation of flavonoids as potential anticancer agents Novotný, Lukáš Pour, Milan Kučerová, Marta Charles University Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry University of Limoges Faculty of Pharmacy Laboratory of Natural Substances Chemistry Consultants: prof. RNDr. Milan Pour, Ph.D., Dr. Christelle Pouget Student: Lukáš Novotný Title of Thesis: Synthesis and characterisation of flavonoids as potential anticancer agents With more than 3 million new cases and 1.7 million deaths each year, cancer represents the second most important cause of morbidity in Europe. Search for new anticancer agents is one of the most important ways to improve treatment and management of cancer. At present, around 50 % of drugs against cancer are natural compounds or have a natural origin. Flavonoids, 2- phenyl-1,4-benzopyrones derivatives, are known for their antioxidant, anti-inflammatory, vasculoprotective, antimicrobial and anticancer properties. This project focuses on flavonoids with open C ring, named chalcones. The synthesis of two original molecules is described: one bichalcone and a combined chalcone-polyamine, prepared for the purpose of screening antiproliferative effect on cancer cell lines. The chalcone derivatives were made using Claisen- Schmidt condensation and Suzuki reaction. Different synthetic approaches are discussed. Presently, the two products are... 2016 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-348068 eng info:eu-repo/semantics/restrictedAccess
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language English
format Dissertation
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description Charles University Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry University of Limoges Faculty of Pharmacy Laboratory of Natural Substances Chemistry Consultants: prof. RNDr. Milan Pour, Ph.D., Dr. Christelle Pouget Student: Lukáš Novotný Title of Thesis: Synthesis and characterisation of flavonoids as potential anticancer agents With more than 3 million new cases and 1.7 million deaths each year, cancer represents the second most important cause of morbidity in Europe. Search for new anticancer agents is one of the most important ways to improve treatment and management of cancer. At present, around 50 % of drugs against cancer are natural compounds or have a natural origin. Flavonoids, 2- phenyl-1,4-benzopyrones derivatives, are known for their antioxidant, anti-inflammatory, vasculoprotective, antimicrobial and anticancer properties. This project focuses on flavonoids with open C ring, named chalcones. The synthesis of two original molecules is described: one bichalcone and a combined chalcone-polyamine, prepared for the purpose of screening antiproliferative effect on cancer cell lines. The chalcone derivatives were made using Claisen- Schmidt condensation and Suzuki reaction. Different synthetic approaches are discussed. Presently, the two products are...
author2 Pour, Milan
author_facet Pour, Milan
Novotný, Lukáš
author Novotný, Lukáš
spellingShingle Novotný, Lukáš
Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
author_sort Novotný, Lukáš
title Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
title_short Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
title_full Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
title_fullStr Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
title_full_unstemmed Syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
title_sort syntéza a charakterizace flavonoidů jako potenciálních protinádorových látek
publishDate 2016
url http://www.nusl.cz/ntk/nusl-348068
work_keys_str_mv AT novotnylukas syntezaacharakterizaceflavonoidujakopotencialnichprotinadorovychlatek
AT novotnylukas synthesisandcharacterisationofflavonoidsaspotentialanticanceragents
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