Resynchronizace a prosynchronizace u trvalé kardiostimulace u dětí.
1 Abstract Objectives: To evaluate the results of permanent epicardial pacing and clinical impact of electromechanical dyssynchrony in permanent cardiac pacing in children; to identify the pacing sites with the greatest potential to prevent pacing-induced cardiomyopathy. Methods: Retrospective obser...
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| Format: | Doctoral Thesis |
| Language: | Czech |
| Published: |
2016
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| Online Access: | http://www.nusl.cz/ntk/nusl-347461 |
| Summary: | 1 Abstract Objectives: To evaluate the results of permanent epicardial pacing and clinical impact of electromechanical dyssynchrony in permanent cardiac pacing in children; to identify the pacing sites with the greatest potential to prevent pacing-induced cardiomyopathy. Methods: Retrospective observational study of long-term results of permanent epicardial pacing in children in the Czech Republic. Multi-centre cross-sectional study on long-term effects of the site of ventricular pacing on left ventricular (LV) synchrony and function in children with structurally normal heart, requiring permanent pacing. Results: Overall probability of continued epicardial pacing (absence of change to a partial or total transvenous system) was 92.8 and 76.1% at 5 and 10 years after implantation, respectively. None of those patients who were paced from the systemic ventricle developed dyssynchronous systemic ventricular failure. Pacing site was the only significant predictor of LV ejection fraction (EF) and LV shortening fraction (P < 0.0001 for both). Pacing from the LV apex/LV midlateral wall was associated with preserved LV function (LV ejection fraction ≥ 55%; odds ratio (OR) = 8.26; P = 0.018). Pacing from the RV outflow tract/lateral RV predicted significantly decreased LV function (LV ejection fraction < 45%; OR =... |
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