Studium lisovatelnosti tabletovin pro matricové tablety s dvěma typy směsných suchých pojiv.

• Main Author: Grufíková, Tereza
• Other Authors: Mužíková, Jitka
• Format: Dissertation
• Language: Czech
• Published: 2016
• Online Access: http://www.nusl.cz/ntk/nusl-346927

The thesis studies compressibility of tableting materials for matrix tablets with two types of coprocessed dry binders, namely Prosolv® SMCC 90 and MicroceLac® 100. Carbomers, concretely Carbopol® 71 G NF, were used as polymers in hydrophilic matrix tablets. Glycerol - dibehenate in Compritol® 888 ATO was used in lipophilic matrix tablets. Concentrations of retardant components were 15 and 30 %. The compressibility of tableting materials was evaluated by energy profile of the compaction process and the tensile strength of tablets. The values of total energy of compression increased with a compression force. Tableting materials with Prosolv® SMCC 90 showed higher values than tableting materials with MicroceLac® 100. The plasticity decreased with the compression force, tableting materials with Prosolv® SMCC 90 showed higher values. For these tableting materials, the highest values were in the case of mixtures with 15% concentration of retardant components.