Studium lisovatelnosti tabletovin pro matricové tablety s dvěma typy směsných suchých pojiv.
The thesis studies compressibility of tableting materials for matrix tablets with two types of coprocessed dry binders, namely Prosolv® SMCC 90 and MicroceLac® 100. Carbomers, concretely Carbopol® 71 G NF, were used as polymers in hydrophilic matrix tablets. Glycerol - dibehenate in Compritol® 888 A...
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| Format: | Dissertation |
| Language: | Czech |
| Published: |
2016
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| Online Access: | http://www.nusl.cz/ntk/nusl-346927 |
| Summary: | The thesis studies compressibility of tableting materials for matrix tablets with two types of coprocessed dry binders, namely Prosolv® SMCC 90 and MicroceLac® 100. Carbomers, concretely Carbopol® 71 G NF, were used as polymers in hydrophilic matrix tablets. Glycerol - dibehenate in Compritol® 888 ATO was used in lipophilic matrix tablets. Concentrations of retardant components were 15 and 30 %. The compressibility of tableting materials was evaluated by energy profile of the compaction process and the tensile strength of tablets. The values of total energy of compression increased with a compression force. Tableting materials with Prosolv® SMCC 90 showed higher values than tableting materials with MicroceLac® 100. The plasticity decreased with the compression force, tableting materials with Prosolv® SMCC 90 showed higher values. For these tableting materials, the highest values were in the case of mixtures with 15% concentration of retardant components. |
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