Příprava derivátů tetrazolu s vysokou antimykobakteriální aktivitou a základní in vitro hodnocení jejich toxicity

• Main Author: Kavková, Věra
• Other Authors: Macháček, Miloslav
• Format: Dissertation
• Language: Czech
• Published: 2016
• Online Access: http://www.nusl.cz/ntk/nusl-344080

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Věra Kavková Supervisor: Mgr. Miloslav Macháček Consultant: PharmDr. Jaroslav Roh, Ph.D. Title od diploma thesis: Synthesis of tetrazole derivatives with high antimycobacterial activity and their initial in vitro toxicity assessment Tuberculosis is still one of the most dangerous and widespread infection diseases causing deaths of more than 1.5 million people worldwide each year. Tuberculosis is a specific disease with a complicated treatment and unique pathogenesis and disease progression. Mycobacterium tuberculosis complex strains represent the most common progenitor of tuberculosis. The disease itself is treatable nowadays and its diagnosis is very well established. On the other hand it is still causing fatal problems especially in immunosuppressant and HIV positive patients not only in developing countries. Another unmissable problem is also alarming increase of strains resistant to standardly used antituberculosis treatment. Hence in order to eradicate inception and spreading of the resistant strains the emphasis is on the development engaged in the research for new and more effective antituberculotics which would make treatment of this disease easier and faster especially in...