| Summary: | Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Cardiff University, Cardiff School of Pharmacy and Pharmaceutical Sciences, Drug Delivery Department, Wales, United Kingdom Candidate: Kateřina Rudecká Supervisor: Doc. PharmDr. Kateřina Vávrová, Ph.D Dr. Charles M. Heard, Ph.D. Title of diploma thesis: The anti-inflammatory effects of creams based on a pomegranate extract and their penetration to the skin. To affected people, inflammatory skin diseases mean an unpleasant life experience. Unfortunately, side effects of currently the most widely used drugs for skin diseases - topically applied corticosteroids, are also often involved. That is probably why we can see a growth in the popularity of natural products in recent years. Among these hidden and newfound treasures undoubtedly belongs pomegranate, a fruit used for thousands of years and now again popularized for its antioxidant, anti-inflammatory and anticancer properties. In this study, we formulated creams consisting of Emulsifying ointment BP 15% w/w as an excipient in combination with various oils, with a focus on pomegranate seed oils (PSO, manufactured one and bought one), constituting 15% w/w. The aqueous phase containing pomegranate rind extract (PRE) made 70% w/w. These...
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