| Summary: | Jana Zadražilová Effects of obesity and sleeve gastrectomy on fungiform papillae in a model of Wistar rat Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Obesity has become a worldwide issue in which taste sensitivity and food preferences play crucial roles. The most effective treatment of morbidly obese patients is bariatric surgery. In our preliminary study, we tried to determine the effect of diet induced obesity and sleeve gastrectomy (SG) on the histology of rat tongue, especially how they affect the number of fungiform papillae (FP). Male Wistar rats were used in the experiment. After inducing obesity with a high-fat diet (HFD), some of the rats underwent SG, some had sham surgery and others stayed surgery-free to be considered as a control group, additionally, one group stayed on normal diet (ND) the entire duration of the experiment. After 16 weeks, all rats were sacrificed and histological examination of rat tongue was per- formed. The highest mean number of FP (5.11±1.45) was counted in diet induced obese rats that were fed a ND the last four weeks of the experiment. The lowest number of FP (3.38±1.45) was found in the experimental group of rats fed a HFD through- out the experiment, but underwent SG after 12 weeks of fattening. There was no...
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