Design and synthesis of rutaecarpine analogs as potential cytotoxic agents for cancer chemotherapy treatment

• Main Author: Pešek, Tadeáš
• Other Authors: Kučerová, Marta
• Format: Dissertation
• Language: English
• Published: 2015
• Online Access: http://www.nusl.cz/ntk/nusl-333483

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Tadeáš Pešek Supervisor: PharmDr. Marta Kučerová, Ph.D., Charles University in Prague, Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Thesis Title: Design and synthesis of rutaecarpine analogs as potential cytotoxic agents for cancer chemotherapy treatment Cancer is a progressive multifactorial collection of diseases that causes disorders and decreases quality of life of patients and in some cases results in death. Cancer can affect people of all ages, sexes and races and can be diagnosed in tissues of whole body. It is the second leading cause of death in the world after cardiovascular disorders. There are many ways how to treat cancer and they variy with each type of cancer. Nowadays treatment of cancer is based on surgery, chemotherapy, radiotherapy, biological treatment, immunotherapy and hormonal therapy. Chemotherapy represents the basis of cancer cure and is often used in combination with other approaches for tumour treatment and maximal effect of therapy and to prevent and cure metastases. Chemotherapy consists of cytotoxic agents that induce apoptosis by various pathways. These drugs interfere with cell cycle of all body cells but, in...