Epidemiologie přecitlivělosti u pacientů s atopickým ekzémem a její klinický význam

• Main Author: Liška, Martin
• Other Authors: Panzner, Petr
• Format: Doctoral Thesis
• Language: Czech
• Published: 2014
• Online Access: http://www.nusl.cz/ntk/nusl-332288

Epidemiology of hypersensitivity in patiens with atopic dermatitis and its clinical relevance MUDr. Martin Liška Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease which is often accompanied by hypersensitivity to various allergens. While food allergens have been considered to play a major role in AD pathogenesis, there is also increasing evidence that aeroallergens are involved. The clinical relevance of detected hypersensitivity was also intensively investigated in last decades. Aims of the study: Our aim was to find out the frequency of hypersensitivity to airborne allergens in AD patients and its clinical relevance using various evaluation standards. Methods: We tested 71 patients (median age 5 years) with AD for hypersensitivity to grass and birch pollen, Dermatophagoides pteronyssinus and Dermatophagoides farinae using atopy patch test (APT), skin prick test (SPT) and specific IgE measurement. The sensitivity (SE) and specificity (SP) of the tests were calculated on the basis of personal history of AD exacerbation, SCORAD changes and the number of days with need for topical anti- inflammatory treatment (AITD) in relation to exposure to the allergens being tested. Results: APT was positive in 45 patients, mostly to Der.farinae (n = 37). SPT and/or specific IgE were positive in 42...