Tetrazoly jako potenciální antituberkulotika

• Main Author: Sander, Daniel
• Other Authors: Hrabálek, Alexandr
• Format: Dissertation
• Language: Czech
• Published: 2013
• Online Access: http://www.nusl.cz/ntk/nusl-324936

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Daniel Sander Consultant: Prof. PharmDr. Alexandr Hrabálek, CSc. Title of Thesis: Tetrazoles as potential antituberculotics The development of new antituberculotics has recently become the subject of interest of many pharmaceutical companies. The disease's pharmacotherapy is very demanding on the health system as well as pacient compliance, neither of which are on a sufficient level in the developing countries. As a result, multiresistant strains evolve and those, becoming practically untreatable, pose a serious threat even to the western civilization. Many pharmaceutical laboratories including the KAOCH of FaF are searching for new and more effective agents. One of the contributions to the field of research is also this diploma thesis. The subject of the thesis was the synthesis of series of substituted 1-aryl-1H-tetrazol- 5-thioles and a combination of three antituberculotically promising structural elements, 1-aryl-1H-tetrazole as a ground structure, an alkylated atom of sulfur connected to an electrondeficient carbon atom and an implementation of nitro groups. Final structures were reached through a few synthetic steps including both reactions known and new. The Hodgkins...