| Summary: | AUTHOR: Tereza Neuwirthová TITLE: Intensive medicine II - Life threatening bleeding and hemorrhagic shock FORM: Master Thesis NAME OF UNIVERSITY: Charles University in Prague, Faculty of Pharmacy in Hradec Králové DEGREE: Pharmacy KEY WORDS: Life threatening bleeding, coagulopathy, alternative solutions, transfusion preparations, crystalloid, disseminated intravascular coagulation, shock, peripartum bleeding GOAL: The goal of thesis was to gather and analyse current information about pathophysiology and life threatening bleeding treatment options with focus on liquid shock treatment, prevention and treatment for coagulation disorder during hemorrhagic shock. MAIN FINDINGS: Life threatening bleeding often comes of polytrauma and in relation to childbirth. It is connected with many complications. Restoring of hemostatic mechanisms includes correction of hypothermia, acidosis and other homeostasis parameters. Bleeding source examination, circulating volume substitution and support of organic functions are inseparable part of methods to support coagulation. The goal of these measures is to prevent the progress of hemorrhagic shock related to multi-organ failure. Fresh frozen plasma, thrombocyte concentrates, transfusion preparations containing fibrinogen and coagulation factors concetrates are widely...
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