| Summary: | Prorenin receptor (PRR) plays in the human organism an important role. It is involved in the renin-angiotensin system (RAS), one of the body's major mechanisms important for maintaining the constant plasma concentration of electrolytes. PRR is being used as a therapeutic target for treatment of hypertension and other related diseases. Interestingly, recent studies suggest that PRR is also involved in the Wnt signalling pathway. The Wnt pathway is RAS-independent, evolutionary conserved processes mediating cell signalling. For these reasons, it is of high importance to have proper understanding of PRR function and possible consequences of its inhibition. A homolog of the gene encoding human PRR was found in the genome of the nematode C. elegans. The name of this gene is R03E1.2. In this thesis function of the gene R03E1.2 in the model organism C. elegans was studied. Expression of R03E1.2 during the C. elegans development was monitored with the use of quantitative PCR (qPCR). The gene R03E1.2 is expressed throughout the development of the organism, but primarily during larval development. Localization of the protein R03E1.2 tissue expression in vivo was studied with the use of C. elegans lines expressing protein R03E1.2 tagged with green fluorescent protein (GFP). The protein R03E1.2 is mainly...
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