Nové přístupy v léčbě makulárních edémů sítnice. (Intravitreální aplikace triamcinolon acetonidu)

• Main Author: Dusová, Jaroslava
• Other Authors: Hejcmanová, Dagmar
• Format: Doctoral Thesis
• Language: Czech
• Published: 2012
• Online Access: http://www.nusl.cz/ntk/nusl-309462

New approaches in the treatment of macular edema. Intravitreal triamcinolone acetonide application. We evaluate the efficacy of 4 mg intravitreal triamcinolone injection (IVTA) in patients with macular edema (ME) of various etiology. This prospective study included 54 eyes. Group I consisted of 30 eyes with diabetic macular edema (DME), group II included 16 eyes with ME after retinal vein occlusion and group III contained 8 eyes with cystoid macular edema (CME) after standard cataract surgery. All patients were examined prior to injection and at the 1, 3, 6, 9 and 12 months as followed: the best corrected visual acuity (BCVA) using ETDRS charts, intraocular pressure (IOP) by applanation tonometry, anterior segment and macula biomicroscopy at the slit lamp. Colour fundusphotography was done and macular thickness (MT) was measured by optical coherence tomography (OCT). In all groups of ME, the reduction of MT and improvement of BCVA was observed during and at the end of the study. Mean BCVA in group I improved from 0.19 to 0.23 and MT decreased from 518µm to 375µm. Statistically significant improvement of BCVA (p<0,05) was demonstrated for 1, 3, 6 and 9 months after IVTA. At the 12th month follow up improvement of BCVA was not significant (p=0,057). Reduction of ME was significant in all follow up...