Sublingvální aplikace léčiv. 5

• Main Author: Čižinská, Lucie
• Other Authors: Doležal, Pavel
• Format: Dissertation
• Language: Czech
• Published: 2012
• Online Access: http://www.nusl.cz/ntk/nusl-307108

Thesis brings detailed information about sumatriptan succinate, its therapeutic use and dosage forms. In particular, it notes its sublingual administration. Then it provides a summary description of migraine as a pathophysiological unit. The experimental part is focused on the evaluation of in vitro transmucosal permeation of sumatriptan through porcine sublingual membrane. In the first set of experiments sumatriptan succinate was used in three aqueous vehicle in the second part as nanofibre or cast polymer membranes. Acceptor phase was always a phosphate buffer pH 7.4. Determination of sumatriptan permeated was performed by HPLC. For a 3% sumatriptan phosphate buffer pH 7.4 solution and citrate buffer pH 3.4 were pertinent values of fluxes J about 50 [µg/cm2 .h-1 ], about 40 [µg/cm2 .h-1 ], respectively. Very low permeation was found at 1% solution sumatriptan in artificial salivary fluid. The evaluation of sumatriptan fluxes in transmucosal permeation from polymeric membranes brought important results. Very low fluxes provided the cast of polyacrylic acid (PAA) membranes containing 10% of sumatriptan: J = 0.29 ± 0.07 [µg/cm2.h-1]. Surprisingly high values were measured from polyvinylalcohol (PVA) cast membrane containing 10% of sumatriptan J = 6.5 [µg/cm2 .h-1 ] and from the nanofiber PVA...