Vývoj syntézy 3,5-disubstituovaných gama-laktamů

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Klára Coufalová Consultant: Prof. RNDr. Milan Pour, PhD. Title of Thesis: Synthetic studies of 3,5-disubstituted gamma-lactams The aim of my thesis was to synthesize lactam ana...

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Main Author:	Coufalová, Klára
Other Authors:	Pour, Milan
Format:	Dissertation
Language:	Czech
Published:	2012
Online Access:	http://www.nusl.cz/ntk/nusl-304264

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spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-3042642017-06-28T04:15:47Z Vývoj syntézy 3,5-disubstituovaných gama-laktamů Synthetic studies of 3,5-disubstituted gamma-lactams Coufalová, Klára Pour, Milan Kuneš, Jiří Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Klára Coufalová Consultant: Prof. RNDr. Milan Pour, PhD. Title of Thesis: Synthetic studies of 3,5-disubstituted gamma-lactams The aim of my thesis was to synthesize lactam analogues of hydrolytically and enzymatically unstable 3,5-disubstituted five-membered lactone rings possessing an antifungal effect. I have tried to develop the preparation of 5-(acyloxymethyl)- -3-(4-methoxyfenyl)-1H-2,5-dihydropyrrol-2-one, however, even application of two reaction pathways did not (for now) successfully lead to the desired five-membered lactam ring. 2012 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-304264 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Klára Coufalová Consultant: Prof. RNDr. Milan Pour, PhD. Title of Thesis: Synthetic studies of 3,5-disubstituted gamma-lactams The aim of my thesis was to synthesize lactam analogues of hydrolytically and enzymatically unstable 3,5-disubstituted five-membered lactone rings possessing an antifungal effect. I have tried to develop the preparation of 5-(acyloxymethyl)- -3-(4-methoxyfenyl)-1H-2,5-dihydropyrrol-2-one, however, even application of two reaction pathways did not (for now) successfully lead to the desired five-membered lactam ring.
author2	Pour, Milan
author_facet	Pour, Milan Coufalová, Klára
author	Coufalová, Klára
spellingShingle	Coufalová, Klára Vývoj syntézy 3,5-disubstituovaných gama-laktamů
author_sort	Coufalová, Klára
title	Vývoj syntézy 3,5-disubstituovaných gama-laktamů
title_short	Vývoj syntézy 3,5-disubstituovaných gama-laktamů
title_full	Vývoj syntézy 3,5-disubstituovaných gama-laktamů
title_fullStr	Vývoj syntézy 3,5-disubstituovaných gama-laktamů
title_full_unstemmed	Vývoj syntézy 3,5-disubstituovaných gama-laktamů
title_sort	vývoj syntézy 3,5-disubstituovaných gama-laktamů
publishDate	2012
url	http://www.nusl.cz/ntk/nusl-304264
work_keys_str_mv	AT coufalovaklara vyvojsyntezy35disubstituovanychgamalaktamu AT coufalovaklara syntheticstudiesof35disubstitutedgammalactams
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Vývoj syntézy 3,5-disubstituovaných gama-laktamů

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