Klinický význam použití nových technologií při vedení mimotělního oběhu

• Main Author: Svitek, Vladimír
• Other Authors: Harrer, Jan
• Format: Doctoral Thesis
• Language: Czech
• Published: 2010
• Online Access: http://www.nusl.cz/ntk/nusl-299732

The clinical relevance of implementation of new technologies in extracorporeal circulation Summary Background: An organism's inflammatory response related to cardiopulmonary bypass (CPB) use is caused by activation of immune system cells with the production of a whole spectrum of mediators, whose activity can result in organ dysfunction. Current research, in trying to eliminate the negative effects of CPB, is engaging in innovating technology of systems for CPB. One of the last complex innovations is the so-called miniinvasive cardiopulmonary bypass. Till now though, the clinical benefits of using this system has not been clearly proven. Methods: A group of 54 patients, who were indicated for elective coronary surgery were randomised into two groups - group cCPB (patients operated on using classic CPB in the open modification) and group mCPB (patients operated on using minicircuit). We monitored and compared concentration of interleukin-6, polymorphonuclear elastase, monocyte chemoattractant protein-1, interleukin-10 and soluble receptors for tumour necrosis factor-α in both groups during operation and postoperatively. At the same time we compared the postoperative clinical course. Results: Both groups did not differ in the basic pre and peroperative characteristics (age, EuroScore, ejection fraction,...