Sledování změn koagulace během fyziologické gravidity

• Main Author: Ptáčková, Veronika
• Other Authors: Hronek, Miloslav
• Format: Dissertation
• Language: Czech
• Published: 2008
• Online Access: http://www.nusl.cz/ntk/nusl-292602

This project monitored changes of coagulation during physiological pregnancy by metering of choice coagulation parameters. Includes also the summary of coagulation changes near gravid women and complications that are may their owing to come. For change monitoring was measured value of Protrombin test (PT), Activated parcial tromboplastine test (APTT) and level of fibrinogen (FBG) and D-dimer (DDI) near healthy of gravid women in time up to 20., 30. and 40. week of pregnancy. Metering was effected on Dade Behrings analyzer in haematology laboratory CHL and TC General faculty hospital Prague. Outcomes were statistically processed. Was found, that the value of coagulation tests PT (P=0,0793) and APTT (P=0,1232) not show during pregnancy any relevant changes, happens only to their mild fall in terms of physiological divide. On the contrary, level FBG (P<0,0001) and DDI (P=0,0311) during pregnancy increased. Values of all parameters depend on a week pregnancy. Pregnancy is hypercoagulation state, which is effected above all decrease fibrinolytic activities and products of placenta. Imbalance among for- and anticoagulative action is able to make many complications, threating mother also fetus. Hypercoagulation conditions bear to also found increased levels of FBG and DDI.