Adherence k farmakologické léčbě idiopatických střevních zánětů

• Main Author: Červený, Petr
• Other Authors: Vlček, Jiří
• Format: Doctoral Thesis
• Language: Czech
• Published: 2008
• Online Access: http://www.nusl.cz/ntk/nusl-291393

Aim of the work The aim of the work was to analyze patient's adherence (compliance) to the pharmacotherapy of inflammatory bowel disease in Czech Republic, as well as to analyze quantity and character of potential drug interactions in medications of the tested kohort. Our aims were : 1. to analyze adherence to pharmacotherapy of IBD: o in the patients cohort followed up in the single IBD Unit (Gastroenterological Centre, the 4th Medical Department, Prague) o in the patients cohort followed up in a few gastroenterological ambulancies in the Czech Republic 2. to analyze potential drug interactions in medications of IBD patients Results 1. Adherence to pharmacotherapy of IBD in the patients cohort followed up in the single IBD Unit (Gastroenterological Centre of the 4th Medical department, Prague) 177 patients were enrolled in the study (84 male, 93 female, 117 CD, 60 UC). The patients evaluated their adherence to the pharmacological treatment in an interview. From 47 patients, treated by mesalazine, the urine sample for HPLC analysis of mesalazine was taken. The data was processed by descriptive statistics and factor analysis. 18.6 % of patients admitted they minimally once in the past voluntarily discontinuated their treatment, without their gastroenterologist's consent. A voluntary lowering of the...