Alterace kardiovaskulárního systému endokrinně podmíněných hypertenzí, diagnostické a léčebné aspekty
aj This study contributes to knowledge of pathophysiology and organ complication in endocrine hypertension, especially in primary hyperaldosteronism and pheochromocytoma. Study in patients with pheochromocytoma showed higher arterial stiffness due to catecholamine overproduction. In this study we po...
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| Format: | Doctoral Thesis |
| Language: | Czech |
| Published: |
2007
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| Online Access: | http://www.nusl.cz/ntk/nusl-288087 |
| Summary: | aj This study contributes to knowledge of pathophysiology and organ complication in endocrine hypertension, especially in primary hyperaldosteronism and pheochromocytoma. Study in patients with pheochromocytoma showed higher arterial stiffness due to catecholamine overproduction. In this study we pointed out that predominantly norepinephrine levels and concomitant high blood glucose levels were independently associated with arterial stiffness. Similarly, a study in patients with primary hyperaldosteronism showed higher arterial stiffness in comparison with a comparable group of essential hypertension. This finding should be one of the factors which contribute to higher cardiovascular morbidity and mortality in patients with primary hyperaldosteronism. A study of biochemical markers of endothelial dysfunction has still showed contradictory conclusions. The position of the markers in clinical practice has not been resolved yet. In our study, we did not reveal any convincing evidence of differences in the levels of biochemical markers of endothelial dysfunction between the essential and endocrine hypertensions. The contemporary accepted marker of endothelial dysfunction and atherosclerosis is C-reactive protein as a marker of a chronic low inflammation process. Our study in patients with... |
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