| Summary: | Deep venous thrombosis (DVT) is 3 most cardiovascular disease is one of the most frequent disease at all. In the CR year clinically Diagnosed 15 000-25 000 cases 2 DVT. Despite a number of active tools for the prevention of venous thrombosis is still facing high prevalence of the disease. Epidemiological studies EPI-GETBO 5 of 2000, proves this fact or findings venographically duplex ultrasound proven DVT. By monitoring the 340 000 persons during 1 year was 1.24 cases detected DVT and 0.6 case of pulmonary embolism per every 1000 monitored persons. For people aged over 75 years the incidencesharply increases, DVT has been diagnosed in every hundredth person. In clinical practice still faces many factors that contribute a high incidence of DVT. These include increasing the number ofoccurrence malignant disease that is accompanied by secondary thromboembolism, or mass distribution of some protrombofilních medication. The fault may also be yet undiscovered genetic predisposition for venous thrombophilia or some infectious agents. On the other hand, the total number of detected cases reflect improved diagnosis of these conditions 7 . Advances in diagnosis using modern methods of molecular Genetics reveals another important risk factor - an inherited thrombophilia. These also include the factor V Leiden...
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