| Summary: | Pertussis is a disease with high infectiousness, caused by gramnegative bacteria Bordetella pertussis. Bordetella colonizes the respiratory epithelium and induces typical symptoms. The main factors of pathogenesis are filamentous hemaglutin (FHA), pertussis toxin (PT), pertactin (PRN), fimbrial agglutinogens (fim2, fim3). The disease has three stages - catarrhal, paroxysmal and recovery. Cultivation method is used as a diagnostical proof. The causal therapy of pertussis is antibiotical therapy, especially macrolides. Pertussis is a disease preventable by vaccination. In 1958, the routine vaccination was started in Czech Republic by whole cell vaccine. There was a significant decrease of incidence of pertussis after that. During the 90's the incidence has gently grown up again. Pertussis was an infant disease before (children up to 5 years of age). Nowadays we can see an age shift to adolescents and adults. Pertusis is most dangerous for children younger than one year. The infection of the adults could be mild or even asymptomatic. The whole cell vaccine has often side effects, which are worse with raising age and frequency of sticks. In 2007 there was a new vaccination schedule introduced in Czech Republic which contains a new acellular vaccine. There are fewer side effects after vaccination with acellular...
|
|---|
