Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně

Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně

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New notions about cell development, cell cycle, differentiation and cell signalling are now being used for refinement of classification of malignant lymphomas (ML) and for development of new drugs specifically targeting deregulated proteins some of which play a role in immune signalling. The first s...

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Main Author: Švec, Alexandr
Other Authors: Mandys, Václav
Format: Doctoral Thesis
Language:English
Published: 2007
Online Access:http://www.nusl.cz/ntk/nusl-282287
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spelling ndltd-nusl.cz-oai-invenio.nusl.cz-2822872018-10-03T04:29:21Z Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně Expression of adaptor protein PAG/Cbp in non-neoplastic and neoplastic lymphoid tissue Švec, Alexandr Mandys, Václav Plank, Lukáš Kodet, Roman Stöckbauer, Petr New notions about cell development, cell cycle, differentiation and cell signalling are now being used for refinement of classification of malignant lymphomas (ML) and for development of new drugs specifically targeting deregulated proteins some of which play a role in immune signalling. The first step in most of the signalling pathways is transduction of the signal through the plasma membrane mediated by a plasma cell receptor. Certain proximal signalling molecules such as a family of Src-kinases (SFK) are segregated in particular plasma membrane compartments called lipid rafts or glycosphingolipid-enriched microdomains (GEM). I studied expression of PAG in non-neoplastic and neoplastic lymphoid tissue in order to determine its expression pattem and to investigate its utility in routine diagnostic haematopathology. 2007 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-282287 eng info:eu-repo/semantics/restrictedAccess
collection NDLTD
language English
format Doctoral Thesis
sources NDLTD
description New notions about cell development, cell cycle, differentiation and cell signalling are now being used for refinement of classification of malignant lymphomas (ML) and for development of new drugs specifically targeting deregulated proteins some of which play a role in immune signalling. The first step in most of the signalling pathways is transduction of the signal through the plasma membrane mediated by a plasma cell receptor. Certain proximal signalling molecules such as a family of Src-kinases (SFK) are segregated in particular plasma membrane compartments called lipid rafts or glycosphingolipid-enriched microdomains (GEM). I studied expression of PAG in non-neoplastic and neoplastic lymphoid tissue in order to determine its expression pattem and to investigate its utility in routine diagnostic haematopathology.
author2 Mandys, Václav
author_facet Mandys, Václav
Švec, Alexandr
author Švec, Alexandr
spellingShingle Švec, Alexandr
Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
author_sort Švec, Alexandr
title Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
title_short Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
title_full Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
title_fullStr Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
title_full_unstemmed Exprese adaptace u proteinu PAG/Cbp v non-neoplastické a neoplastické lymfatické tkáně
title_sort exprese adaptace u proteinu pag/cbp v non-neoplastické a neoplastické lymfatické tkáně
publishDate 2007
url http://www.nusl.cz/ntk/nusl-282287
work_keys_str_mv AT svecalexandr expreseadaptaceuproteinupagcbpvnonneoplastickeaneoplastickelymfaticketkane
AT svecalexandr expressionofadaptorproteinpagcbpinnonneoplasticandneoplasticlymphoidtissue
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